Acetic Anhydride → (4-Chloro-6-methylpyridin-2-yl)methyl acetate

HRID 1357030Notes

Reaction equation

HRID 1357030 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N+:5]([O-])=[C:4]([CH3:10])[CH:3]=1.[C:11]([O:14]C(=O)C)(=[O:13])[CH3:12]>>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH2:10][O:14][C:11](=[O:13])[CH3:12])[CH:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 5878434-Chloro-2,6-dimethylpyridine 1-oxide

Product 1

HCID 18505252(4-Chloro-6-methylpyridin-2-yl)methyl acetate

Procedure

4.0 g (25.4 mmol) of 4-chloro-2,6-dimethylpyridine-1-oxide was dissolved in 12 ml of acetic anhydride. The resultant solution was gradually heated to raise the temperature to the reflux temperature, and the solution was then stirred overnight at the same temperature. The reacted solution was then condensed under reduced pressure to obtain a crude product of acetic 4-chloro-6-methyl-2-pyridinylmethyl ester.

Workup

  1. temperatureto raise the temperature to the reflux temperature
  2. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-b874bf9cc70649c696331d3670e0b7f4
Source dataset
uspto-grants-2003_07
Patent number
US06589967B1

Reaction notes

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