(2,4-Dichlorophenyl)acetyl chloride → Ethyl 3-(2,4-dichlorophenylacetylamino)-3-(3-nitrophenyl)-propionate

HRID 1357073Notes

Reaction equation

HRID 1357073 reaction equation
[ClH:1].[NH2:2][CH:3]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=1)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].Cl[C:20]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:21]=1[CH2:27][C:28](Cl)=[O:29]>>[Cl:1][CH:27]([C:21]1[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][CH:20]=1)[C:28]([NH:2][CH:3]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=1)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])=[O:29]

Participants

3

Reactant 2

HCID 2758147(2,4-Dichlorophenyl)acetyl chlorideHCID 16188861Ethyl 3-amino-3-(3-nitrophenyl)propanoate hydrochloride

Product 1

HCID 70018101Ethyl 3-(2,4-dichlorophenylacetylamino)-3-(3-nitrophenyl)-propionate

Procedure

Corresponding to Example 3a, 5.0 g of (1b) were acetylated by addition of 2,4-dichlorophenylacetyl chloride. A white solid was obtained (yield: 3.1 g).

Workup

  1. customA white solid was obtained (yield: 3.1 g)

Sources & evidence

ORD record
ord-5b3d500a80294db4b88674eabadc3c04
Source dataset
uspto-grants-2003_07
Patent number
US06589972B2

Reaction notes

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