Bisindolylmaleimide V → HCID 496503, compound

Participants

Reaction Steps

To a solution of 2,3-bis(1H-indol-3-yl)-N-methylmaleimide (14 mg, 0.04 mmol) synthesized according to a known method (Tetrahedron, Vol. 44, p. 2887, 1988) in DMF (1 mL) was added a small amount of 10% palladium-carbon and the whole was stirred at room temperature for 1 day under hydrogen atmosphere. The palladium-carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (ethyl acetate:n-hexane=2:1) to obtain 3,4-bis(1H-indol-3-yl)-1-methy-2,5-dioxopyrrolidine (12.9 mg, 91.7%) as a mixture of two isomers (A:B=2.7:1.0) as pale red solids.

Provenance & Evidence