Methanol → HCID 18505443, compound

Participants

Reaction Steps

To a solution of 2-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-N-methylmaleimide (60 mg, 0.14 mmol) in MeOH (3 mL) was added a small amount of 10% palladium-carbon, and the whole was stirred at room temperature for 1 day under hydrogen atmosphere. The palladium-carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (dichloromethan:methanol=8:1) to obtain 3-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-1-methyl-2,5-dioxopyrrolidine (49 mg, 81.5%) as pale red solids.

Provenance & Evidence