HCID 15132373, compound → HCID 18505447, compound

Participants

Reaction Steps

To a solution of 2,3-bis(5-methoxy-1H-indol-3-yl)-N-methylmaleimide (100 mg, 0.25 mmol) in DMF (5 mL) was added a small amount of 10% palladium-carbon, and the whole was stirred at room temperature for 1 day under hydrogen atmosphere. The palladium-carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (ethyl acetate:n-hexane=2:1) to obtain 3,4-bis(5-methoxy-1H-indol-3-yl)-1-methyl-2,5-dioxopyrrolidine (20 mg, 19.9%) as a mixture of two isomers (A:B=2:1) as pale red solids.

Provenance & Evidence