HCID 18505436, compound → HCID 18505433, compound

Participants

Reaction Steps

To a solution of 2,3-bis(5-methoxy-1-methyl-1H-indol-3-yl)-N-methylmaleimide (70 mg, 0.16 mmol) in DMF (2 mL) was added a small amount of 10% palladium-carbon, and the whole was stirred at room temperature for 1 day under hydrogen atmosphere. The palladium-carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (ethyl acetate:n-hexane=2:1) to obtain 3,4-bis(5-methoxy-1-methyl-1H-indol-3-yl)-1-methyl-2,5-dioxopyrrolidine (42 mg, 60.4%) as pale red solids.

Provenance & Evidence