HCID 15132338, compound → HCID 18505446, compound

Participants

Reaction Steps

A small amount of 10% palladium-carbon was added to a solution of 2,3-bis(1H-indol-3-yl)N-phenylmaleimide (55 mg, 0.14 mmol) dissolved in DMF (2 mL), and the whole was stirred at room temperature for 1 day under hydrogen atmosphere. The palladium-carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (ethyl acetate:n-hexane=2:1) to obtain 3,4-bis(1H-indol-3-yl)-1-phenyl-2,5-dioxopyrrolidine (36 mg, 56.1%) as pale red solids.

Provenance & Evidence