1-benzyl-3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione → HCID 10550007, compound

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Reaction Steps

To a solution of 2,3-bis(1H-indol-3-yl)-N-benzylmaleimide (35 mg, 0.084 mmol) in DMF (1 mL) was added a small amount of 10% palladium-carbon, and the whole was stirred at room temperature for 6 hours under hydrogen atmosphere. The palladium-carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (ethyl acetate:n-hexane=2:1) to obtain 3,4-bis(1H-indol-3-yl)-1-benzyl-2,5-dioxopyrrolidine (32.1 mg, 91.3%) as pale red solids.

Provenance & Evidence