Cyclopropanecarboxylic acid → HCID 22250517, compound

HRID 1357124Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH:11]([CH2:23][C:24]([NH:26][OH:27])=[NH:25])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH:28]1([C:31](O)=O)[CH2:30][CH2:29]1>>[CH:28]1([C:31]2[O:27][N:26]=[C:24]([CH2:23][CH:11]3[CH2:10][CH2:9][CH:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)[N:12]3[S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:14])=[O:15])[N:25]=2)[CH2:30][CH2:29]1

Participants

Reactant 2

HCID 15655Cyclopropanecarboxylic acid

HCID 178427376HCID 178427376, compound

Product 1

HCID 22250517HCID 22250517, compound

Procedure

The title compound, pale yellow oil, MS: m/e=442.3 (M+H+) was prepared in accordance with the general method of example 13 from (2RS,5SR)-2-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-N-hydroxy-acetamidine and cyclopropyl-carboxylic acid.

Sources & evidence

ORD record: ord-ef38d35459654e6e846322521cb89d9b
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06589978B2

Reaction notes

Loading…