Methanesulfonyl chloride → HCID 9955607, compound

HRID 1357136Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH:11](NCCC)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:27][S:28](Cl)(=[O:30])=[O:29]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[N:12]([S:13]([C:16]3[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=3)(=[O:15])=[O:14])[CH:11]([CH2:9][CH2:10][CH2:11][NH:12][S:28]([CH3:27])(=[O:30])=[O:29])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 69596828HCID 69596828, compound

Product 1

HCID 9955607HCID 9955607, compound

Procedure

Reaction of (2RS,5RS)-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propylamine with methanesulfonyl chloride according to the general method of example Id yielded the title compound as a white solid, m.p. =123° C. and MS: m/e=455.3 (M+H+).

Sources & evidence

ORD record: ord-0a8daf3bfe1e4a4f87b8a6dff02ad935
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06589978B2

Reaction notes

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