HCID 22250442, compound → HCID 22250447, compound

HRID 1357146Notes

Reaction equation

HRID 1357146 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[N:6]1[S:17]([C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18].[CH3:27][C:28]1[NH:32][N:31]=[N:30][N:29]=1>>[F:16][C:13]1[CH:14]=[CH:15][C:10]([CH:7]2[N:6]([S:17]([C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)(=[O:18])=[O:19])[CH:5]([CH2:4][CH2:3][CH2:2][N:29]3[C:28]([CH3:27])=[N:32][N:31]=[N:30]3)[CH2:9][CH2:8]2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 22250442HCID 22250442, compoundHCID 178434708HCID 178434708, compound

Product 1

HCID 22250447HCID 22250447, compound

Procedure

The title compound, colorless oil, MS: m/e=444.4 (M+H+), was prepared in accordance with the general method of example 82b from (2RS,5RS)-2-(3-chloro-propyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine and 5-methyl-1H-tetrazole.

Sources & evidence

ORD record
ord-51a368763cdb408082d4ae1e474b833b
Source dataset
uspto-grants-2003_07
Patent number
US06589978B2

Reaction notes

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