Chloroform → HCID 69596802, compound

HRID 1357158Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[C@H:11]([CH2:23][CH2:24][CH2:25][OH:26])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH:27](Cl)(Cl)Cl>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[CH2:9][CH2:10][C@@H:11]([CH2:23][CH2:24][CH2:25][O:26][CH3:27])[N:12]2[S:13]([C:16]2[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=2)(=[O:15])=[O:14])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6212Chloroform

HCID 69596721HCID 69596721, compound

Product 1

HCID 69596802HCID 69596802, compound

Procedure

The title compound, colorless oil, MS: m/e=392.1 (M+H+) and [α]D20=−82.7° (c=0.2682 in chloroform), was prepared in accordance with the general method of example 8 from (2S,5S)-3-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propan-1-ol.

Sources & evidence

ORD record: ord-184f1ce41f1a42e0908be2a584d03925
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06589978B2

Reaction notes

Loading…