Imidazole → HCID 22250436, compound

HRID 1357174Notes

Reaction equation

HRID 1357174 reaction equation
Cl[CH:2]([CH3:28])[CH2:3][CH2:4][CH2:5][CH:6]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[N:7]1[S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=1)(=[O:20])=[O:19].[NH:29]1[CH:33]=[CH:32][N:31]=[CH:30]1>>[F:17][C:14]1[CH:13]=[CH:12][C:11]([CH:8]2[N:7]([S:18]([C:21]3[CH:22]=[CH:23][C:24]([CH3:27])=[CH:25][CH:26]=3)(=[O:19])=[O:20])[CH:6]([CH2:5][CH2:4][CH2:3][CH2:2][CH2:28][N:29]3[CH:33]=[CH:32][N:31]=[CH:30]3)[CH2:10][CH2:9]2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 22250533HCID 22250533, compound

Product 1

HCID 22250436HCID 22250436, compound

Procedure

The title compound, colorless oil, MS: m/e 456.5 (M+Ht), was prepared in accordance with the general method of example 82b from (2RS,5RS)-2-(4-chloro-pentyl)-5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine and 1H-imidazole.

Sources & evidence

ORD record
ord-cfd7e51ac4b9440486739efb0c16c739
Source dataset
uspto-grants-2003_07
Patent number
US06589978B2

Reaction notes

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