6-(benzyloxy)methyl-3,5-dimethyl-4-methoxymethoxy-2H-pyran-2-one → 3,5-dimethyl-6-hydroxymethyl-4-methoxymethoxy-2H-pyran-2-one

Participants

Reaction Steps

20% Pd(OH)2/C (360 mg) was added to a solution of 6-(benzyloxy)methyl-3,5-dimethyl-4-methoxymethoxy-2H-pyran-2-one (1.80 g) in EtOH (50 ml), and the mixture was vigorously stirred at room temperature for 3 hours under a hydrogen gas atmosphere. The reaction solution was celite filtered and the mother liquor was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/AcOEt=1/1) to obtain 3,5-dimethyl-6-hydroxymethyl-4-methoxymethoxy-2H-pyran-2-one.

Provenance & Evidence