Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → Methyl 5-(dimethoxymethyl)benzofuran-2-carboxylate

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Reaction Steps

Methyl orthoformate (1.0 g) and polymer-bound PPTS (1.0 g) were added to a solution of methyl 5-formylbenzofuran-2-carboxylate (15 g) in MeOH (100 ml), and after allowing the mixture to stand at room temperature for 8 hours, the reaction solution was filtered and the mother liquor was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/AcOEt=9/1) to obtain methyl 5-(dimethoxymethyl)benzofuran-2-carboxylate.

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