Lithium hydroxide, monohydrate → HCID 54712960, compound

Participants

Reaction Steps

An aqueous solution (30 ml) of LiOH-hydrate (465 mg) was added to a solution of 4-acetyloxy-6-(benzofuran-2-yl)-3,5-dimethyl-2H-pyran-2-one (3.00 g) in MeOH (100 ml) at 0° C., and after stirring at room temperature for 2 hours, the MeOH was distilled off under reduced pressure. The residue was rinsed with Et2O, and then a KHSO4 aqueous solution was added at 0° C. for adjustment to pH 2.0. The precipitated crystals were filtered off and thoroughly rinsed with water and Et2O in that order and then dried to obtain 6-(benzofuran-2-yl)-3,5-dimethyl-4-hydroxy-2H-pyran-2-one.

Provenance & Evidence