1,4-Dioxane → HCID 18505628, compound

Participants

Reaction Steps

To a solution of 3,5-dimethyl-4-methoxymethoxy-6-(5-nitrobenzofuran-2-yl)-2H-pyran-2-one (100 mg) in dioxane (20 ml) and EtOH (20 ml) there was added 5% Pd/C (5 mg), and after displacing the reaction vessel atmosphere with hydrogen, the mixture was stirred at room temperature overnight. The reaction solution was filtered and concentrated, and then purified by silica gel thin-layer chromatography (n-hexane/AcOEt=1/1) to obtain 6-(5-aminobenzofuran-2-yl)-3,5-dimethyl-4-methoxymethoxy-2H-pyran-2-one and 3,5-dimethyl-6-(5-(ethylamino)benzofuran-2-yl)-4-methoxymethoxy-2H-pyran-2-one.

Provenance & Evidence