Water → HCID 10167270, compound

Participants

Reaction Steps

A mixture of 2-{1-bromo-6-[(2-butyl-benzofuran-3-carbonyl)-amino]-naphthalen-2-yloxy}-3-phenyl-propionic acid methyl ester (139 mg, 0.231 mmol), prepared in the previous step, and 1 N NaOH (231 μL, 0.231 mmol) in 75 mL of methanol was refluxed for 4 h. By TLC starting material remained. Water (10 mL) and 1 N NaOH (231 μL, 0.231 mmol) were added and the mixture refluxed for 18 h (overnight). The reaction was filtered and 2 mL of 1 N HCL was added to the filtrate. The filtrate was concentrated under reduced pressure to remove the methanol. The solid formed was collected by filtration, rinsed with water and dried under reduced pressure to give the title compound (111 mg, 81%) as a white solid, mp 191-195° C.

Provenance & Evidence