Potassium Carbonate → HCID 69137546, compound

Participants

Reaction Steps

A mixture of (5-bromo-6-hydroxy-naphthalen-2-ylmethyl)-carbamic acid tert-butyl ester (0.89 g, 2.5 mmol), prepared in the previous step, potassium carbonate (1.7 g, 12.5 mmol), and methyl bromoacetate (1.26 mL, 2.75 mmol) in 10 mL of DMF was stirred under nitrogen for 18 h (overnight). The reaction was diluted with ethyl acetate and extracted three times with water. The organic layer was dried (MgSO4) and the solvent removed under reduced pressure to give [1-bromo-6-(tert-butoxycarbonylamino-methyl)-naphthalen-2-yloxy]-acetic acid methyl ester (1.016 g, 96%) as an off white solid, mp 96-100° C.

Provenance & Evidence