Bromine → HCID 86587378, compound

Participants

Reaction Steps

Bromine (210 μL, 4.02 mmol) in 50 mL of glacial HOAc was added under nitrogen dropwise over 2 h to a solution of 2-butyl-benzofuran-3-carboxylic acid (6-hydroxy-naphthalen-2-ylmethyl)-amide (1.5 g, 4.02 mmol), prepared in step 2 of Example 8, in 300 mL of glacial HOAc at room temperature. After the addition the reaction was stirred at room temperature for 20 h (overnight). The solid formed was collected by filtration and dried under reduced pressure to give 2-butyl-benzofuran-3-carboxylic acid (5-bromo-6-hydroxy-naphthalen-2-ylmethyl)-amide (1.41 g, 81%) as a light gray solid, mp 192-193° C.

Provenance & Evidence