Potassium Carbonate → HCID 86587377, compound

Participants

Reaction Steps

A mixture of 2-butyl-benzofuran-3-carboxylic acid (5-bromo-6-hydroxy-naphthalen-2-ylmethyl)-amide (300 mg, 0.66 mmol), prepared in the previous step, bromoacetonitrile (56 μL, 0.80 mmol) and potassium carbonate (460 mg, 3.32 mmol) in 15 mL of DMF was stirred under nitrogen at room temperature for 18 h (overnight). The reaction was diluted with ethyl acetate, extracted multiple times with water, dried (MgSO4) and the solvent removed under reduced pressure to give 2-butyl-benzofuran-3-carboxylic acid (5-bromo-6-cyanomethoxy-naphthalen-2-ylmethyl)-amide (324 mg, 99%) as an off-white solid, mp154-157° C.

Provenance & Evidence