Potassium Carbonate → HCID 12083563, compound

Participants

Reaction Steps

A mixture of 2-butyl-benzofuran-3-carboxylic acid (6-hydroxy-5-p-tolyl-naphthalen-2-ylmethyl)-amide (252 mg, 0.54 mmol), prepared in the previous step, bromoacetonitrile (55 μL, 0.81 mmol) and potassium carbonate (378 mg, 2.73 mmol) in 15 mL of DMF was stirred under nitrogen at room temperature for 19 h (overnight). The reaction was diluted with ethyl acetate, extracted multiple times with water, dried (MgSO4) and the solvent removed under reduced presure to give 2-butyl-benzofuran-3-carboxylic acid (6-cyanomethoxy-5-p-tolyl-naphthalen-2-ylmethyl)-amide (269 mg, 99%) as a light brown solid, mp 114-117° C.

Provenance & Evidence