Potassium Carbonate → HCID 12083565, compound

Participants

Reaction Steps

A mixture of 2-butyl-benzofuran-3-carboxylic acid [6-hydroxy-5-(4-methoxy-phenyl)-naphthalen-2-ylmethyl]-amide (301 mg, 0.63 mmol), prepared in the previous step, bromoacetonitrile (52 μL, 0.75 mmol) and potassium carbonate (434 mg, 3.14 mmol) in 20 mL of DMF was stirred under nitrogen at room temperature for 21 h (overnight). The reaction was diluted with ethyl acetate, extracted multiple times with water, dried (MgSO4) and the solvent removed under reduced pressure to give 2-butyl-benzofuran-3-carboxylic acid [6-cyanomethoxy-5-(4-methoxy-phenyl)-naphthalen-2-ylmethyl]-amide (325 mg, 99%) as a brown solid, mp 139-142° C.

Provenance & Evidence