Hydrochloric Acid → HCID 10282804, compound

Participants

Reaction Steps

1 N NaOH (300 μL, 0.30 mmol) was added under nitrogen to a solution of 2-[6-{[(2-butyl-benzofuran-3-carbonyl)-amino]-methyl}-1-(4-chloro-phenyl)-naphthalen-2-yloxy]-3-phenyl-propionic acid methyl ester (182 mg, 0.28 mmol), prepared in the previous step, in 30 mL of methanol plus 2.5 mL of water at room temperature. After the addition the reaction was stirred at room temperature overnight. If starting material remains additional 1 N NaOH is added until the reaction is complete. A total of 900 μL of 1 N NaOH was added. The reaction was acidified by the addition of 1.6 mL of 1 N HCl and then concentrated under reduced pressure. The solid that formed was collected by filtration and dried under reduced pressure to give the title compound (166 mg, 94%) as a white solid, mp 169-172° C.

Provenance & Evidence