Bromine → HCID 86587384, compound

Participants

Reaction Steps

A solution of bromine in 40 mL glacial acetic acid was added dropwise under nitrogen over 2.5 h to a solution of 2-butyl-benzofuran-3-carboxylic acid (6-hydroxy-naphthalen-2-ylmethyl)-methyl-amide (0.5364 g, 1.358 mmol), prepared in the previous step, in 60 mL of glacial acetic acid. The reaction stirred for 20 h (overnight). The solvent was removed under reduced pressure. The residue was diluted with methylene chloride, extracted with 5% NaHCO3, dried (MgSO4) and the solvent removed under reduced pressure to give 2-butyl-benzofuran-3-carboxylic acid (5-bromo-6-hydroxy-naphthalen-2-ylmethyl)-methyl-amide (0.6981 g, 100%.) as a light yellow foam, MS m/z: 466 [M+H]+.

Provenance & Evidence