Potassium Carbonate → HCID 12083572, compound

Participants

Reaction Steps

A mixture of 2-butyl-benzofuran-3-carboxylic acid (6-hydroxy-naphthalen-2-ylmethyl)-methyl-amide (0.90 g, 2.32 mmol), prepared in step-4 of Example 31, bromoacetonitrile (0.194 mL, 2.79 mmol) and potassium carbonate (1.6 g, 11.6 mmol) in 10 mL DMF was stirred under nitrogen at room temperature for 24 h (overnight). The reaction was diluted with ethyl acetate and extracted five times with water. The organic layer was dried (MgSO4) and the solvent removed under reduced pressure to give 2-butyl-benzofuran-3-carboxylic acid (6-cyanomethoxy-naphthalen-2ylmethyl)-methyl-amide (0.94 g, 95%) as a brown oil, MS m/z: 427 [M+H]+.

Provenance & Evidence