Oxalyl chloride → HCID 18505311, compound

Participants

Reaction Steps

Oxalyl chloride (5.89 mL, 66.1 mmol) was added under nitrogen to a solution of 2-butyl-1-methyl-1H-indole-3-carboxylic acid (3.06 g, 13.2 mmol), prepared in the previous step, in 100 mL of methylene chloride at room temperature. There was an immediate evolution of gas. After the addition the reaction was stirred at room temperature for 2 h. The solvent was removed under reduced pressure. To remove excess oxalyl chloride the residue was dissolved in benzene and the solvent removed under reduced pressure to give 2-butyl-1-methyl-1H-indole-3-carbonyl chloride as a brown oil. The material was immediately used without additional purification.

Provenance & Evidence