反应详情

Bromine (556 μL, 10.8 mL) in 10 mL of glacial HOAc was added under nitrogen dropwise over 1 h to a solution of 6-methoxy-naphthalene-2-carbaldehyde (2.01 g, 10.8 mmol) in 25 mL of glacial HOAc at room temperature. After the addition the reaction was stirred at room temperature for 2 h. The solid was collected by filtration, rinsed with glacial HOAc and dried under reduced pressure to give 5-bromo-6-methoxy-naphthalene-2-carbaldehyde (2.27 g, 79%) as a tan solid, mp 148-150° C.

1. additionAfter the addition the reaction
2. filtrationThe solid was collected by filtration
3. washrinsed with glacial HOAc
4. customdried under reduced pressure