Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → 5-Bromo-6-methoxy-naphthalene-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 6-Methoxynaphthalene-2-carbonitrile | HCID 349173 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 5-Bromo-6-methoxy-naphthalene-2-carbonitrile | HCID 18505335 | 88% |
반응 단계
Bromine (7.0 mL, 0.137 mol) in 100 mL of glacial HOAc was added under nitrogen dropwise over 4 h to a solution of 6-methoxy-naphthalene-2-carbonitrile (25.02 g, 0.137 mol) in 700 mL of glacial HOAc at room temperature. After the addition the reaction was stirred at room temperature overnight. The solid that formed was collected by filtration, rinsed with glacial HOAc and dried under reduced pressure to give 5-bromo-6-methoxy-naphthalene-2-carbonitrile (31.35 g, 88%) as a white solid, mp 177-178° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06589970B2 |
| 출처 데이터셋 | uspto-grants-2003_07 |
| ORD ID | ord-74ae69ad48b24a59abd662eb5ca083ec |
| 출처 메모 | uspto-grants-2003_07 |