Potassium Carbonate → HCID 12083584, compound

Participants

Reaction Steps

A mixture of 3-phenylethyl-benzofuran-2-carboxylic acid (5-bromo-6-hydroxy-naphthalen-2-ylmethyl)-methyl-amide, prepared in step 4 of Example 45, methyl bromoacetate (260 μL, 2.75 mmol) and potassium carbonate (1.58 g, 11.96 mmol) in 25 mL of DMF was stirred under nitrogen at room temperature 16 h (overnight). The reaction was partitioned between ethyl acetate and water. The organic layer was separated, extracted multiple times with water, dried (MgSO4) and the solvent removed under reduced pressure to give (1-bromo-6-{[methyl-(3-phenethyl-benzofuran-2-carbonyl)-amino]-methyl}-naphthalen-2-yloxy)-acetic acid methyl ester (1.29 g, 96%) as a light brown foam, MS m/z: 586 [M+H]+.

Provenance & Evidence