2-Methylbenzofuran-3-carbonyl Chloride → 2-Methyl-benzofuran-3-carboxylic acid butyl-(6-hydroxy-naphthalen-2-ylmethyl)-amide

Participants

Reaction Steps

Prepared in the same manner as described in step 4 of Example 48 and replacing 6-(benzylamino-methyl)-naphthalen-2-ol with 6-butylaminomethyl-naphthalen-2-ol, prepared in step 3 of Example 51, and replacing 2-butyl-benzofuran-3-carbonyl chloride with 2-methy-benzofuran-3-carbonyl chloride, prepared in step 2 of Example 20. Purification of the crude product on 300 g silica gel (230-400 mesh) using 25%-33% ethyl acetate in hexane as the eluent gave 2-methyl-benzofuran-3-carboxylic acid butyl-(6-hydroxy-naphthalen-2-ylmethyl)-amide (1.03 g, 47%) as a tan solid, mp 126-128° C.

Provenance & Evidence