Hydrochloric Acid → HCID 10188204, compound

Participants

Reaction Steps

A mixture of 2-(1-bromo-6-{[(2-ethyl-benzofuran-3-carbonyl)-amino]-methyl}-naphthalen-2-yloxy)-3-phenyl-propionic acid methyl ester (0.200 g, 0.341 mmol), prepared in the previous step, 1N NaOH (1.02 mL, 1.02 mmol), 10 mL of water and 100 mL of methanol was stirred under nitrogen at room temperature for 20 h (overnight). The reaction was acidified with 1N HCl until acidic by litmus paper. The methanol was removed under reduced pressure. The solid that precipitated and was collected by filtration and dried under reduced pressure to give the title compound (0.0576 g, 29%) as a white solid, mp 162-165° C.

Provenance & Evidence