Potassium Carbonate → HCID 19261492, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-hydroxyphthalic acid dimethyl ester (1.23 g, 5.95 mmol), o-fluoronitro-benzene (0.81 ml, 7.64 mmol), and potassium carbonate (1.66 g, 12 mmol) in dry DMF (25 ml) was heated at 100° C. for 1 hour. The mixture was cooled to room temperature, filtered and the filtrate evaporated to dryness in vacuo to give 4-(2-nitrophenoxy)phthalic acid dimethyl ester as a yellow oil (yield: 1.97 g, (100%)). 1H—NMR (CDCl3) in ppm: δ 3.9 (6H, 2xs); 7.1-7.2 (2H,m); 7.2 (1H,d); 7.3-7.4 (1H,m); 7.6-7.7 (1H,m); 7.84 (1H,d); 8.03 (1H, d.d.).

Provenance & Evidence