2-Bromo-5-nitrobenzoyl chloride → [2,4-Bis-(2-bromo-4-nitrobenzoylamino)phenoxy]phthalic acid dimethyl ester

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4-[2,4-Bis-(2-bromo-4-nitrobenzoylamino)phenoxy]phthalic acid dimethyl ester (Compound 113) from 4-(2,4-diaminophenoxy)phthalic acid dimethyl ester (0.53 g) and 2-bromo-5-nitrobenzoyl chloride (1.0 g). The crude product purified on silica gel column (eluent: methylene chloride:methanol (5:1)) to give 4-([2,4-bis-(2-bromo-4-nitrobenzoylamino)phenoxy]phthalic acid dimethyl ester as brownish crystals (yield: 0.81 g 63%). Mp: 138-142° C. LC/MS: 794 (M+Na), 773 (MH+), 740 (M—OMe). CHN: Calculated: C: 46.66; H: 2.61; N: 7.25; Br: 20.69. Found C: 47.05; H: 2.94; N: 6.85; Br: 20.22.

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