HCID 86589713, compound → HCID 18506137, compound

Participants

Reaction Steps

A mixture of 4-[2-chloro-6-(3-nitrobenzoylamino)phenoxy]benzenesulfonic acid 2,2-dimethyl-propyl ester (52 mg, 0.10 mmol) and tetraethyl ammonium chloride (54 mg, 0.5 mmol) in DMF (5 ml) was stirred at reflux temperature for 24 hours. The reaction mixture was evaporated and purified on preparative HPLC (Gilson semi-prep.column prep-NOVA-PaK®HRC18, 6 microM, 60 Å; Flow 15 ml/min Gradient: 5-100% MeCN in water (20 min)) to give 4-[2-chloro-6-(3-nitrobenzoylamino)phenoxy]benzenesulfonic acid (yield 22 mg (25%)). LC/MS: m/e 449 (M+).

Provenance & Evidence