Ammonium Chloride → HCID 178474116, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-{2-[3-cyano-4-(1H-tetrazol-5-yl)phenoxy]phenoxy}acetamide and N-{2-[4-cyano-3-(1H-tetrazol-5-yl)phenoxy]phenyl}acetamide (0.45 g, 1.4 mmol) was dissolved in dry DMF (20 ml). Ammonium chloride (0.17 g, 3.1 mmol), sodium azide (0.2 g, 3.1 mmol), and lithium chloride (0.13 g, 3.1 mmol) were added. The reaction mixture was heated at 120° C. for 120 hours. The reaction mixture was evaporated in vacuo and purified on a silica gel column (eluent:methylene chloride/methanol (2:1)). The yielded oil was used without any further purification in the next step.

Provenance & Evidence