Hydrochloric Acid → HCID 18506136, compound

Participants

Reaction Steps

N-{2-[3,4-Bis-(1-benzyl-1H-tetrazol-5-yl)phenoxy]phenyl}acetamide (40 mg, 0.07 mmol) was dissolved in ethanol (10 ml). 4N hydrochloric acid (10 ml) was added and the reaction mixture was refluxed for 15 hours. The mixture was evaporated in vacuo and redissolved in methylene chloride and 0.5 N aqueous sodium hydroxide (1:1) (20 ml). The organic phase was dried over magnesium sulphate and evaporated in vacuo to give 2-[3,4-bis-(1-benzyl-1H-tetrazol-5-yl)phenoxy]phenylamine as an oil (yield: 37 mg (100%)). 1H-NMR (CDCl3 in ppm): 3.9 (2H, broad s); 5.58 (4H, s); 6.75 (1H, d.d.); 6.85 (1H,d.d.); 6.9 (1H,d.d.); 7.0 (1H,d.d.); 7.1 (1H,d.d.); 7.2-7.4 (10H,m); 7.48 (1H,d); 7.8 (1H,d).

Provenance & Evidence