HCID 18506135, compound → HCID 18506092, compound

HRID 1357392Notes

Reaction equation

HRID 1357392 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+]([O-])=O)=[CH:4][C:3]=1[CH2:11][C:12]([NH:14][C:15]1[CH:33]=[CH:32][CH:31]=[CH:30][C:16]=1[O:17][C:18]1[CH:19]=[C:20]([C:27]([OH:29])=[O:28])[C:21](=[CH:25][CH:26]=1)[C:22]([OH:24])=[O:23])=[O:13].COC(=O)C1C(=CC(OC2C=CC=CC=2NC(=O)CC2C=C([N+:63]([O-:65])=[O:64])C=CC=2Cl)=CC=1)C(OC)=O>O>[N+:63]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:11][C:12]([NH:14][C:15]1[CH:33]=[CH:32][CH:31]=[CH:30][C:16]=1[O:17][C:18]1[CH:19]=[C:20]([C:27]([OH:29])=[O:28])[C:21](=[CH:25][CH:26]=1)[C:22]([OH:24])=[O:23])=[O:13])([O-:65])=[O:64]

Participants

4

Reactant 2

HCID 18506135HCID 18506135, compound2×HCID 69995838HCID 69995838, compound

Product 1

HCID 18506092HCID 18506092, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-{2-[2-(2-Chloro-5-nitrophenyl)acetylamino]phenoxy}phthalic acid (Compound 175) from 4-{2-[2-(2-chloro-5-nitrophenyl)acetylamino]phenoxy}phthalic acid dimethyl ester as white crystals (yield: 26 mg (74%)). Mp: 176-178.2° C. LC/MS: m/e 470 (MH+), 453 (MH+-H2O).

Sources & evidence

ORD record
ord-ca4084da8fbe4679b9a9575b8ea6b992
Source dataset
uspto-grants-2003_07
Patent number
US06590118B1

Reaction notes

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