HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5R)-2-iodo-5-(6-quinolyl)-5-(triethylsilyloxy)-2-pentene → (5R)-2-iodo-5-(6-quinolyl)-5-hydroxy-2-pentene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5R)-2-iodo-5-(6-quinolyl)-5-(triethylsilyloxy)-2-pentene | HCID 86586614 | — |
| Solvent | AcOH THF water | HCID 21877175 | — |
| Product | (5R)-2-iodo-5-(6-quinolyl)-5-hydroxy-2-pentene | HCID 86586613 | — |
Reaction Steps
A solution of (5R)-2-iodo-5-(6-quinolyl)-5-(triethylsilyloxy)-2-pentene (2.26 g) in 50 mL of 3:1:1 acetic acid/THF/water is stirred at ambient temperature for 8 hours, then concentrated. The residue is dissolved in ethyl acetate, washed sequentially with sat. NaHCO3 and brine, then dried over MgSO4, filtered, and evaporated. The product is purified by SiO2 chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06589968B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-d0132a35104940bda294966c848d7896 |
| Source note | uspto-grants-2003_07 |