HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 69507500, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorotriethylsilane | HCID 13819 | — |
| Reactant | (4S)-3-[(2S,3S,6R,7S,8S)-5-oxo-3-hydroxy-2,4,4,6,8-pentamethyl-7-(2,2,2-trichloroethoxycarbonyloxy)-10-undecenoyl]-4-benzyloxazolidinone | HCID 59922965 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69507500 | HCID 69507500 | — |
Reaction Steps
A solution of (4S)-3-[(2S,3S,6R,7S,8S)-5-oxo-3-hydroxy-2,4,4,6,8-pentamethyl-7-(2,2,2-trichloroethoxycarbonyloxy)-10-undecenoyl]-4-benzyloxazolidinone (2.6 g), imidazole (0.48 g), and triethylsilyl chloride (0.68 g) in 5 mL of dimethylformamide is stirred for 2 hours at ambient temperature, then poured into water and extracted with ether. The extract is washed with sat. aq. NaCl, dried over MgSO4, filtered, and evaporated. The product is purified by chromatography on SiO2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06589968B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-0c895976b0ea4c5ca0afb0c17c2e1eaf |
| Source note | uspto-grants-2003_07 |