p-Toluenesulfonic acid → HCID 136436396, 화합물

HRID 1357457노트

반응식

HRID 1357457 반응식
[CH3:1][NH:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]=O)[C:5]=1[OH:12].C1(C)C=CC(C2C(C([NH:28][NH2:29])=O)=CC=CC=2)=CC=1.[C:31]1([CH3:41])[CH:36]=[CH:35][C:34](S(O)(=O)=O)=[CH:33][CH:32]=1>CO>[CH3:1][NH:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]=[N:28][NH:29][C:34]2[CH:35]=[CH:36][C:31]([CH3:41])=[CH:32][CH:33]=2)[C:5]=1[OH:12]

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 13937904'-Methylbiphenyl-2-carbohydrazideHCID 11344339HCID 11344339, 화합물

생성물 1

HCID 136436396HCID 136436396, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
22.5 °C

실험 절차

A soluton of 200 mg (1 mmol) of the aldehyde of Example 4 in 30 ml of anhydrous methanol was reacted with 140 mg (1 mmol) of p-toluenebenzohydrazide with acid catalysis (para-toluenesulfonic acid). After the reaction mixture had been stirred for approximately 14 hours at 20 to 25° C., it was freed from the solvent. 340 mg of the title compound, which corresponded to 99% of theory, were obtained from the residue. (m.p. 108-125° C.)

출처 및 근거

ORD 기록
ord-a78d1716c4904155a4ebe2147fafbf77
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06593315B2

반응 노트

불러오는 중…