HCID 54046142, compound → HCID 69531309, compound

HRID 1357463Notes

Reaction equation

HRID 1357463 reaction equation
[CH2:1]([O:3][C:4]([NH:6][C@H:7]([C:16]([NH:18][C@H:19]([C:24]([NH:26][C@H:27]([C:29](O)=[O:30])[CH3:28])=[O:25])[C@H:20]([CH2:22][CH3:23])[CH3:21])=[O:17])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)=[O:5])[CH3:2].[CH2:32]([O:34][CH:35]([O:47][CH2:48][CH3:49])[CH2:36][C@@H:37]([NH2:46])[CH2:38][C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[CH3:33]>>[CH2:48]([O:47][CH:35]([O:34][CH2:32][CH3:33])[CH2:36][C@@H:37]([NH:46][C:29](=[O:30])[C@H:27]([CH3:28])[NH:26][C:24](=[O:25])[C@H:19]([C@H:20]([CH2:22][CH3:23])[CH3:21])[NH:18][C:16](=[O:17])[C@H:7]([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([OH:15])=[CH:13][CH:14]=1)[NH:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:38][C:39]([O:41][C:42]([CH3:43])([CH3:45])[CH3:44])=[O:40])[CH3:49]

Participants

3

Reactant 2

HCID 54046142HCID 54046142, compoundHCID 57151936HCID 57151936, compound

Product 1

HCID 69531309HCID 69531309, compound

Procedure

Starting from 0.22 g (0.5 mmol) of ethoxycarbonyl-L-tyrosyl-L-isoleucyl-L-alanine (Example 3, Step A6) and 0.13 g (0.5 mmol) of (3R)-3-amino-4-t-butoxycarbonyl-butyraidehyde diethyl acetal (Example 1, Step B4) and using proportional amounts of reagents and solvents, the components are coupled and the end product isolated according to the process described in Example 1, Step A1.

Workup

  1. customthe end product isolated

Sources & evidence

ORD record
ord-c5a201818e5543e2b510e47cd7e366f3
Source dataset
uspto-grants-2003_07
Patent number
US06593300B1

Reaction notes

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