Water → Triphenylphosphine

Participants

Reaction Steps

Triphenylphosphine (1.14 g, 4.35 mmol) was slowly added to a room temperature solution of Example 1K (0.80 g, 2.54 mmol) in THF (30 mL). After stirring for 2 hours, water (3.0 mL) and triethylamine (1.0 mL, 7.19 mmol) were added. The mixture was stirred for 10 hours, and concentrated. The concentrate was chromatographed on silica gel using ethyl acetate to afford the desired product with Ph3P as a contaminant.

Provenance & Evidence