Lithium Hydroxide → HCID 9862103, compound

Participants

Reaction Steps

Aqueous lithium hydroxide solution (0.1N, 15 mL) was added to a room temperature solution of Example 4A (40 mg, 0.118 mmol) in THF (5 mL). The solution was stirred for 10 hours, acidified to pH 5-6 with DOWEX® 50WX2-200 ion-exchange resin, filtered and concentrated. The concentrate was purified by flash chromatography on silica gel using acetic acid/ethyl acetate (1/5) to afford 37 mg (96%) of the desired product as a white solid.

Provenance & Evidence