Lithium Hydroxide → HCID 10220753, compound

Participants

Reaction Steps

Aqueous LiOH solution (0.1N, 15 mL) was added to a room temperature solution of Example 13L (23 mg, 0.085 mmol) in methanol (5 mL). After stirring for 10 hours, the reaction mixture was acidified to pH 5-6 with DOWEX® 50WX2-200 ion-exchange resin, filtered and concentrated. The concentrate was purified by flash chromatography using acetic acid/ethyl acetate (1/5) to afford 20.5 mg (94%) of the desired product as a white solid.

Provenance & Evidence