Allyl bromide → HCID 91611667, compound

Participants

Reaction Steps

Sodium hydride (60%, 35 mg, 0.875 mmol) and allyl bromide (0.051 mL, 0.589 mmol) were added to a 0° C. solution of Example 13L (80 mg, 0.295 mmol) in THF (15 mL). After stirring for 5 hours, the reaction mixture was quenched with saturated NH4Cl, and then extracted with ethyl acetate. The ethyl acetate layer was washed with brine, dried (MgSO4), filtered and concentrated. The concentrate was purified by flash chromatography using ethyl acetate to afford 83 mg (90%) of the desired product as a white solid.

Provenance & Evidence