Potassium Carbonate → HCID 91490383, compound

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Reaction Steps

Potassium carbonate can be added to a room temperature solution of Example 18E in methanol and stirred over night. The reaction mixture can then be filtered, concentrated, and purified to yield the first intermediate compound. Methanesulfonyl chloride can then be added to a 0° C. solution of the first intermediate in dichloromethane. After stirring for up to 12 hours, the reaction mixture can then be washed with saturated NaHCO3, dilute citric acid solution, water, and brine, dried (MgSO4), filtered and concentrated. The concentrate can then be purified to afford the second intermediate. Tetrabutylammonium fluoride can then be added to a room temperature solution of the second intermediate in THF. After stirring for up to 12 hours, the reaction mixture can be diluted with ethyl acetate, washed with water, and brine, dried (MgSO4), filtered and concentrated and purified to afford the desired product.

Provenance & Evidence