HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-bromo-2-chloro-N-phenylpyrimidin-4-amine → 4-Anilino-5-bromo-2-(4-{N-[2-hydroxy-3-(N,N-dimethylamino)propyl]-N-methylamino}anilino)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-bromo-2-chloro-N-phenylpyrimidin-4-amine | HCID 11403389 | — |
| Reactant | 4-{N-[2-hydroxy-3-(N,N-dimethylamino)propyl]-N-methylamino}aniline | HCID 18186457 | — |
| Product | 4-Anilino-5-bromo-2-(4-{N-[2-hydroxy-3-(N,N-dimethylamino)propyl]-N-methylamino}anilino)pyrimidine | HCID 18186501 | — |
Reaction Steps
Using an analogous method to that described in Example 1, but starting from 4-anilino-5-bromo-2-chloropyrimidine (Method 13) and 4-{N-[2-hydroxy-3-(N,N-dimethylamino)propyl]-N-methylamino}aniline (Method 116), the product was obtained. MS (MH+): 471, 473; HPLC (RT): 4.53.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06593326B1 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-b30554a738d147469bbff746c2f4dddb |
| Source note | uspto-grants-2003_07 |