5-bromo-2-chloro-N-phenylpyrimidin-4-amine → HCID 18186502, compound

HRID 1357536Notes

Reaction equation

HRID 1357536 reaction equation
[NH:1]([C:8]1[C:13]([Br:14])=[CH:12][N:11]=[C:10](Cl)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:16][C:17]([CH3:32])([CH2:27][NH:28][CH:29]([CH3:31])[CH3:30])[CH2:18][O:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1>>[NH:1]([C:8]1[C:13]([Br:14])=[CH:12][N:11]=[C:10]([NH:24][C:23]2[CH:25]=[CH:26][C:20]([O:19][CH2:18][C:17]([OH:16])([CH3:32])[CH2:27][NH:28][CH:29]([CH3:30])[CH3:31])=[CH:21][CH:22]=2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 114033895-bromo-2-chloro-N-phenylpyrimidin-4-amineHCID 18186460HCID 18186460, compound

Product 1

HCID 18186502HCID 18186502, compound

Procedure

Using an analogous method to that described in Example 1, but starting from 4-anilino-5-bromo-2-chloropyrimidine (Method 13) and 4-[2-hydroxy-2-methyl-3-(isopropyl amino)propoxy]aniline (Method 118), the product was obtained. MS (MH+): 486, 488; HPLC (RT): 4.26.

Workup

  1. customthe product was obtained
  2. customHPLC (RT)

Sources & evidence

ORD record
ord-9fe50fa5ae9c46288efcb65a8aea92e3
Source dataset
uspto-grants-2003_07
Patent number
US06593326B1

Reaction notes

Loading…