HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Anilino-5-bromo-2-(4-hydroxyanilino)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | 5-bromo-2-chloro-N-phenylpyrimidin-4-amine | HCID 11403389 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 4-Anilino-5-bromo-2-(4-hydroxyanilino)pyrimidine | HCID 22048123 | 32% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
4-Aminophenol (0.73 g, 7.8 mmol) and concentrated hydrochloric acid (1.30 ml, 7.1 mmol) were added to 4-anilino-5-bromo-2-chloropyrimidine (Method 13; 3.0 g, 7.1 mmol) in n-butanol (30 ml), and the mixture was heated at 100° C. for 12 hours. The solid which precipitated out on cooling was filtered off and washed with n-butanol and diethyl ether to give the product (0.80 g, 32%). MS (MH+): 357, 359.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06593326B1 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-6dcb12bae2b14ae6a9ef6a8607332e80 |
| Source note | uspto-grants-2003_07 |